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Genes Involved in Pseudomonas aeruginosa Biofilm-Specific Resistance to Antibiotics
==Genes Involved in Pseudomonas aeruginosa Biofilm-Specific Resistance to Antibiotics==
Pseudomonas aeruginosa is a bacteria characterized by its biofilm formation ability and multiple antibiotic resistance. The studies determine the genes or operons of P. aeruginosa UCBPP-PA14 (ndvB, PA1875–1877 and tssC1) that do not affect biofilm formation but are involved in biofilm-specific antibiotic résistance, and (PA0756–0757, PA2070 and PA5033) increased expression in biofilm cells and they play an important role in biofilm-specific antibiotic resistance.〔Rahme LG, Stevens EJ, Wolfort SF, Shao J, Tompkins RG, et al. (1995) Common virulence factors for bacterial pathogenicity in plants and animals. Science 268: 1899–1902.2.Whiteley M, Bangera MG, Bumgarner RE, Parsek MR, Teitzel GM, et al. (2001) Gene expression in Pseudomonas aeruginosa biofilms. Nature 413: 860–864.3.Mah TF, O'Toole GA (2001) Mechanisms of biofilm resistance to antimicrobial agents. Trends Microbiol 9: 34–39.4.Stewart PS, Costerton JW (2001) Antibiotic resistance of bacteria in biofilms. Lancet 358: 135–138.5.Hoiby N, Bjarnsholt T, Givskov M, Molin S, Ciofu O (2010) Antibiotic resistance of bacterial biofilms.. Int J Antimicrob Agents 35: 322–332.6.MRESEARCH ARTICLE〕
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